On 18 November 2003 the USTR notified the United States Congress of the Administration's intent to initiate free trade agreement (FTA) negotiations with the Republic of Panama. Negotiations began in Panama City, Panama on 26 April 2004.  In February 2006, at the request of the Government of Panama the U.S. agreed to a technical review of the U.S. food safety inspection system. The U.S. President sent to Congress a notice of intent to enter into a free trade agreement with Panama on 30 March 2007. The FTA was signed on 28 June 2007.

Documents related to the negotiations
28 June 2007	Panama and the United States sign Trade Promotion Agreement
30 March 2007	Notice of Intention to Enter into a Free Trade Agreement with Panama
13 February 2006	Statement by US Chief Agriculture Negotiator regarding FTA negotiations
5 April 2005	Ninth round of negotiations
6 February 2005	Eighth round of negotiations
15 January 2005	Seventh round of negotiations
10 December 2004	Sixth round of negotiations
18 August 2004	Joint Statement by Panama and the United States on the fourth round of negotiations
11 June 2004	Joint Statement by Panama and the United States on the second round of negotiations
26 March 2004	U.S. and Panama to initiate negotiations on April 26
18 November 2003	Letter to U.S. House of Representatives notifying intent to initiate free trade talks with Panama
Source:  Ministerio de Comercio e Industrias de Panamá, Office of the United States Trade Representative (USTR)

On 28 June 2007, the USTR released the text of the U.S.-Panama TPA.

June 2007	Final texts of the U.S. - Panama Trade Promotion Agreement
19 January 2007	Draft texts: U.S.-Panama Trade Promotion Agreement
Source: Office of the United States Trade Representative (USTR)

Panama's National Assembly ratified the agreement on 11 July 2007.

11 July 2007	Panama's National Assembly ratifies TPA
Source: Ministerio de Comercio e Industrias de Panamá

• Ministerio de Comercio e Industrias de Panamá
• Office of the U.S. Trade Representative (USTR)